About us

What myBIOS is all about
myBIOS

is a Biotech company founded in 2020 by Claudia Rinnofner. We focus on the production of protein-based (biological) molecules with unique physical and biochemical properties. We are located in Graz at the Zentrum für Wissens- und Technologietransfer in der Medizin (ZWT), Neue Stiftingtalstraße 2 | 8010 Graz, Austria.

Claudia Rinnofner, DI Dr.

Claudia Rinnofner, DI Dr.

Chief Executive Officer

Claudia Rinnofner earned her PhD at Graz University of Technology (TUG) in the research group of Prof. Anton Glieder at the Institute of Molecular Biotechnology. Her doctoral thesis was devoted to the expression of recombinant proteins in Pichia pastoris employing synthetic promoters. Following her PhD she worked at acib GmbH (Austrian Centre of Industrial Biotechnology) in an industrial multi-firm project. Claudia Rinnofner has more than 15 years experience as a scientist, working with Pichia pastoris and strain engineering including the recombinant expression of various heterologous proteins.

Alexander Gutmann, DI Dr.

Alexander Gutmann, DI Dr.

Head of Business Development and Scale-Up

Alexander Gutmann has 14 years of experience in biotechnology research and development. He worked for five years in the CDMO industry at Lonza and Arxada. Alexander managed development and optimization of fermentation and downstream processes and organized scale-up to piloting and commercial manufacturing. He has also a strong academic track record in biocatalysis and related fields. He co-authored more than 20 peer reviewed publications.

Alexandra Deibuk, M.Sc.

Alexandra Deibuk, M.Sc.

Head of Laboratory

Alexandra Deibuk has a bachelor’s degree in Molecular Biology and a master’s degree in Biochemistry and Molecular Biomedicine. She did her masters thesis at Graz University of Technology in collaboration with myBIOS. She is currently working as Lab-Team Leader at myBIOS.

Franziska Gruber, DI

Franziska Gruber, DI

Research Scientist

Franziska Gruber completed her master’s degree in Biotechnology at Graz University of Technology (TUG) in 2023 after studying Molecular Biology as her bachelor’s degree. Her master thesis covered topics of cholesterol-response mechanisms and MAP-kinase signaling in modified Pichia pastoris. In 2024 she joined myBIOS as a scientist.

Lukas Schönleitner, M.Sc.

Lukas Schönleitner, M.Sc.

Research Scientist

Lukas Schönleitner has a bachelor’s degree in Molecular Biology. He did his master in Biotechnology at Graz University of Technology (TUG) in the group of Birgit Wiltschi focusing on non-canonical amino acids. He joined myBIOS in February 2024.

Sandra Flecker, M.Sc.

Sandra Flecker, M.Sc.

Research Scientist (on leave)

Sandra Flecker studied Molecular Biology, Biochemistry and Molecular Biomedicine at University of Graz. She joined myBIOS in 2021. Prior to it she was working in a diagnostics company. She is an experienced scientist, specialised in the field of Pichia pastoris.

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Fotocredits – Helmut Lunghammer

Publications

Felber, M., Pichler, H., Ruth, C., 2014. Strains and molecular tools for recombinant protein production in Pichia pastoris. Methods Mol. Biol. 1152, 87–111. https://doi.org/10.1007/978-1-4939-0563-8_5

Fürst, M., Kerschbaumer, B., Rinnofner, C., Migglautsch, A., Winkler, M., Fraaije, M., 2019. Exploring the Biocatalytic Potential of a Self-Sufficient Cytochrome P450 from <i>Thermothelomyces thermophila</i> Adv. Synth. Catal. https://doi.org/10.1002/adsc.201900076

Hartner, F.S., Ruth, C., Langenegger, D., Johnson, S.N., Hyka, P., Lin-Cereghino, G.P., Lin-Cereghino, J., Kovar, K., Cregg, J.M., Glieder, A., 2008. Promoter library designed for fine-tuned gene expression in Pichia pastoris. Nucleic Acids Res. 36, e76. https://doi.org/10.1093/nar/gkn369

Hashem, C., Stolterfoht, H., Rinnofner, C., Steinberger, S., Winkler, M., Pichler, H., 2020. Secretion of Pseudomonas aeruginosa Lipoxygenase by Pichia pastoris upon Glycerol Feed. Biotechnol. J. 15, 2000089. https://doi.org/10.1002/biot.202000089

Mellitzer, A., Ruth, C., Gustafsson, C., Welch, M., Birner-Grünberger, R., Weis, R., Purkarthofer, T., Glieder, A., 2014. Synergistic modular promoter and gene optimization to push cellulase secretion by Pichia pastoris beyond existing benchmarks. J. Biotechnol. 191. https://doi.org/10.1016/j.jbiotec.2014.08.035

Näätsaari, L., Mistlberger, B., Ruth, C., Hajek, T., Hartner, F.S., Glieder, A., 2012. Deletion of the pichia pastoris ku70 homologue facilitates platform strain generation for gene expression and synthetic biology. PLoS One 7. https://doi.org/10.1371/journal.pone.0039720

Rinnofner, C., Kerschbaumer, B., Weber, H., Glieder, A., Winkler, M., 2019. Cytochrome P450 mediated hydroxylation of ibuprofen using Pichia pastoris as biocatalyst. Biocatal. Agric. Biotechnol. 17, 525–528. https://doi.org/10.1016/J.BCAB.2018.12.022

Ruth, C., Buchetics, M., Vidimce, V., Kotz, D., Naschberger, S., Mattanovich, D., Pichler, H., Gasser, B., 2014. Pichia pastoris Aft1 – a novel transcription factor, enhancing recombinant protein secretion. Microb. Cell Fact. 13, 120. https://doi.org/10.1186/s12934-014-0120-5

Ruth, C., Glieder, A., 2010. Perspectives on synthetic promoters for biocatalysis and biotransformation. ChemBioChem 11. https://doi.org/10.1002/cbic.200900761

Ruth, C., Zuellig, T., Mellitzer, A., Weis, R., Looser, V., Kovar, K., Glieder, A., 2010. Variable production windows for porcine trypsinogen employing synthetic inducible promoter variants in Pichia pastoris. Syst. Synth. Biol. 4. https://doi.org/10.1007/s11693-010-9057-0

Stolterfoht, H., Rinnofner, C., Winkler, M., Pichler, H., 2019. Recombinant Lipoxygenases and Hydroperoxide Lyases for the Synthesis of Green Leaf Volatiles. J. Agric. Food Chem. https://doi.org/10.1021/acs.jafc.9b02690