Technology
Pichia pastoris
Pichia pastoris (renamed Komagataella phaffii) is a well-established and regulatory-approved host organism for industrial protein and enzyme production. The ability to efficiently secrete proteins facilitates downstream processing and reduces production costs.
Established for industrial protein and enzyme production
- High cell densities in inexpensive defined medium
- Stable strains by genomic integration
- Efficient tools for genetic modification
- Well scalable fermentation and downstream processes
Approved by regulatory bodies (EMA/EFSA, FDA, etc.)
- GRAS status (generally recognized as safe)
- Free of endotoxins and viruses
Efficient secretion of recombinant proteins
- Simplified downstream processing (no cell disruption)
- Very low impurities from host cell proteins
Essential features of higher eukaryotic hosts
- Co-and post-translational modifications
- Engineered strains with modified glycosylation patterns